Lu, Xiaofeng

Contact Information Phone: 612-625-9900 Fax: 612-625-7950 Email: luxxx049@umn.edu Address: Department of Neurology University of Minnesota MMC 295, 420 Delaware St SE Minneapolis, MN 55455

Assistant Professor

Primary Hospital Affiliation

University of Minnesota Medical Center, Fairview

Education & Training

Graduate School: Juntendo University, School of Medicine, Tokyo, Japan, 1998
Fellowship:  Brain Science Center, Veterans Administration Medical Center, Department of Neuroscience and Neurology, University of Minnesota, Minneapolis, 1999-2002

Research Interests

• Clinical Neurophysiology, in particular, in Motor Disorder and Epilepsy
• Motor and Cognitive Functions of the Cortex, Basal Ganglia and Cerebellum
• Unraveling the Circuitry of the Central Nervous System

Funded Research

Title: Neural Mechanism for Coordination of Eye and Hand Movements
Principal Investigator, Grants-in-Aid for Scientific Research on Priority Areas (GASRPA) to X. Lu
Agency: Japanese Ministry of Education, Culture, Sports, Science and Technology (JMECSST)

Title: Neural Mechanism of Concept Formation
Principal Investigator, GASRPA to X. Lu
Agency: JMECSST

Title: Artificial Cerebellum
Co-Investigator (P.I.: S. Kitazawa; Animal Model and Single Unite Recording Site P.I.: X. Lu), GASRPA to S. Kitazawa
Agency: JMECSST

Selected Publications

Ohmae S, Lu X*, Takahashi T, Uchida Y, Kitazawa S. Neuronal activity related to anticipated and elapsed time in macaque supplementary eye field. Exp Brain Res 184, 593-598, 2008 (*Corresponding author)

Uchida Y§, Lu X§*, Ohmae S, Takahashi T, Kitazawa S. Neuronal activity related to reward size and rewarded target position in primate supplementary eye field.
J Neurosci 27(50), 13750-13755, 2007 (§These authors contributed equally, *Corresponding author)

Lu X, Miyachi S, Ito Y, Nambu A, Takada M. Topographic distribution of output neurons in cerebellar nuclei and cortex to somatotopic map of primary motor cortex. Eur J Neurosci 25, 2374-2382, 2007

Miyachi S, Lu X, Imanishi M, Sawada K, Nambu A, Takada M. Somatotopically arranged inputs from putamen and subthalamic nucleus to primary motor cortex.
Neurosci Res 56(3), 300-308, 2006

Ashe J, Lungu O, Basford A, Lu X. Cortical control of motor sequences.
Curr Opin in Neurobiol 16, 213-221, 2006

Lu X, Ashe J. Anticipatory activity in primary motor cortex codes memorized movement sequences. Neuron 45, 967-973, 2005

Miyachi S, Lu X, Inoue S, Iwasaki T, Koike S, Nambu A, Takada M. Organization of multisynaptic inputs from prefrontal cortex to primary motor cortex as revealed by retrograde transneuronal transport of rabies virus. J Neurosci 25(10), 2547-2556, 2005

Hikosaka O, Rand MK, Nakamura K, Miyachi S, Kitaguchi K, Sakai K, Lu X, Shimo Y. Long-term retention of motor skill in macaque monkeys and humans. Exp Brain Res 147, 494-504, 2002

Miyachi S, Hikosaka O, Lu X. Differential activation of monkey striatal neurons in the early and late stages of procedural learning. Exp Brain Res 146, 122-126, 2002

Lu X, Matsuzawa M, Hikosaka O. Neural correlates of oculomotor sequences in supplementary eye field. Neuron 34, 317-325, 2002

Rand MK, Hikosaka O, Miyachi S, Lu X, Nakamura K, Kitaguchi K, Shimo Y. Characteristics of sequential movements during early learning period in monkeys. Exp Brain Res 131, 293-304, 2000

Hikosaka O, Nakahara H, Rand MK, Lu X, Nakamura K, Miyachi S, Doya K. Parallel neural networks for learning sequential procedures. Trends Neurosci 22, 464-471, 1999

Hikosaka O, Miyashita K, Miyachi S, Sakai K, Lu X. Differential roles the frontal cortex, basal ganglia, and cerebellum in visuomotor sequence learning. Neurobiol Learn Mem 70, 137-149, 1998

Rand MK, Hikosaka O, Miyachi S, Lu X, Miyashita K. Characteristics of a long-term procedural skill in the monkey. Exp Brain Res 118, 293-297, 1998

Lu X, Hikosaka O, Miyachi S. Role of monkey cerebellar nuclei in skill for sequential movement. J Neurophysiol 79, 2245-2254, 1998