Rothman, Steven

Contact Information Appointments: 612-626-6688 Fax:   Prescription Refill Fax:   Email: srothman@umn.edu Address:

Steven Rothman, M.D.
Professor of Pediatric Neurology

Primary Hospital Affiliation

University of Minnesota Medical Center, Fairview

Eduation & Training

Medical School: State University of New York Upstate Medical Center

Residency: University Of Minnesota (Pediatric internship and residency); Washington University in St Louis (Adult and Child Neurology)

Fellowship: Washington University (Fellowship in Neurobiology)

Clinical Interests

• General Child Neurology
• Pediatric epilepsy
• Experimental epilepsy and mechanisms of action of antiepileptic drugs
• Adrenoleukodystrophy

Research Interests

Dr. Rothman made some of the early observations that suggested a link between endogenous glutamate and a variety of acute and chronic human neurobiological diseases. He and his colleagues now have broad interests in the fundamental neurobiology and therapy of epilepsy. Their most recent epilepsy experiments have investigated a potential new modality of epilepsy therapy, rapid cooling utilizing small thermoelectric (Peltier) devices. They are now trying to extend their initial work on animal seizures to human epilepsy. A second area of research is the potential antiepileptic effect of caged GABA on focal epilepsy. The lab has recently found that GABA uncaging with an LED can rapidly stop focal seizures in rodents. A third research focus is the mechanism of action of the widely used antiepileptic drug levetiracetam. The lab has found that it selectively alters transmitter release during high frequency bursts.

Dr. Rothman's work has been supported by the National Institutes of Health, from which he received a Jacob Javits Award (1989-1996). He has been a member of two NIH study sections and served on the editorial board of the Journal of Neuroscience. He is the author or co-author of over 80 scientific papers and invited reviews and listed in ISI Highly Cited, a data base of the most frequently cited authors of scientific publications.