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Research

Zeenat Qureshi Stroke Research Center was established to conduct innovative and ground breaking research pertaining to cerebrovascular diseases. The center is home to several researchers including two full-time PhDs, one biostatistician, one research nurse coordinator, two research associates, and twelve clinician researchers. The center provides 3500 square feet of research facilities for epidemiological, clinical, and basic research with emphasis on translational designs. Facilities for advanced image analysis, multi-center clinical trials coordination, repository of over 25 longitudinal and cross sectional epidemiological studies, and experimental angiographic unit are important features of the center.

The researchers are funded through several grants from the National Institutes of Health, American Heart Association, and donations from philanthropic sources. In 2007, the research center was ranked in the top 20 academic facilities for conducting biomedical research selected from hundreds of institutions representing several disciplines of biological sciences in the United States by "The Scientist". Teaching, mentoring, and policies were ranked as the strengths of the center.

Current Projects:

Integration of multiple population-based databases. This project seeks to merge large sets of information about medical care for stroke and related disroders so that "data mining" techniques can be used to recognize the complex relationships among patients, doctors, hospitals, insurance plans, treatment plans, disease conditions, and outcomes. The project leader is Dr. Fareed Suri, a medical fellow.

Use of the Jostent Graftmaster coronary graft stent for intracerebral vascular lesions. The Jostent is designed to treat perforations of the arteries of the heart. The Stroke Center is investigating whether the device is safe and effective for treating perforated arteries to the brain. Dr. Adnan Qureshi is the principal investigator.

Interventional Endovascular Delivery of Stem Cells for Treating Stroke. There is evidence that, if stem cells are delivered to the site of a stroke, recovery of neurological function may be enhanced. This project extends the studies to pigs and dogs, in preparation for later human trials. The project leader is Dr. Vallabh Janardhan.

Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH) and Control of Acute Stroke Hypertension (CASH). These two studies seek to determine the best treatment for high blood pressure accompanying a stroke. Critical control of blood pressure immediately after a stroke may minimize damage to the brain. Drs. Adnan Qureshi and Fareed Suri are the investigators.

Carotid Stenting for High Surgical-Risk Patients. This study provides information about the use of stents for problems in the carotid arteries to the brain. These stents are already on the market, but they are used only for special cases and more information is required to be assured of their safety and effectiveness. Dr. Vallabh Janardhan is the investigator in the Stroke Center.

Minnesota Stroke Registry. A grant from the US Centers for Disease Control (CDC) supports a project that will: (1) Collect data on quality care provided to patients treated at hospitals with suspected stroke. (2) Coordinate a Minnesota Stroke Registry Advisory Committee. (3) Develop and implement quality improvement interventions for hospitals statewide. (4) Evaluate progress in stroke care as a result of quality improvements. Dr. Kamakshi Lakshminarayan, of the Stroke Center, is one of the investigators. Click here for more information.

Publications:

Adams HP Jr, del Zoppo G, Alberts MJ, Bhatt DL, Brass L, Furlan A, Grubb RL, Higashida RT, Jauch EC, Kidwell C, Lyden PD, Morgenstern LB, Qureshi AI, Rosenwasser RH, Scott PA, Wijdicks EF. Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atheros Circulation 2007 115(20):e478-534.

Adams HP Jr, del Zoppo G, Alberts MJ, Bhatt DL, Brass L, Furlan A, Grubb RL, Higashida RT, Jauch EC, Kidwell C, Lyden PD, Morgenstern LB, Qureshi AI, Rosenwasser RH, Scott PA, Wijdicks EF. Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atheros Stroke 2007 38(5):1655-711.

Alkawi A, Kirmani JF, Nazli JN, Ezzeddine MA, Hanley DF, Qureshi AI. Management of recurrent cerebral arterial occlusion in a patient with cardiac decompensation. Neurocrit Care 2007 6(2):139-45.

Greenberg E, Janardhan V, Katz JM, Riina H, Zimmerman R, Gobin YP. Disappearance and reappearance of a cerebral aneurysm: a case report. Surg Neurol 2007 67(2):186-8.

Qureshi AI, Alexandrov AV, Tegeler CH, Hobson RW 2nd, Dennis Baker J, Hopkins LN; American Society of Neuroimaging; Society of Vascular and Interventional Neurology. Guidelines for screening of extracranial carotid artery disease: a statement for healthcare professionals from the multidisciplinary practice guidelines committee of the American Society of Neuroimaging; cosponsored by the Society of Vascular and Interven J Neuroimaging 2007 17(1):19-47.

Qureshi AI, Ezzeddine MA, Nasar A, Suri MF, Kirmani JF, Hussein HM, Divani AA, Reddi AS. Prevalence of elevated blood pressure in 563,704 adult patients with stroke presenting to the ED in the United States. Am J Emerg Med 2007 25(1):32-8.

Qureshi AI, Janjua N, Kirmani JF, Harris-Lane P, Suri MF, Zhou J, Divani AA. Mechanical disruption of thrombus following intravenous tissue plasminogen activator for ischemic stroke. J Neuroimaging. 2007 Apr;17(2):124-30. PMID: 17441833 [PubMed - in pro Thrombolysis for ischemic stroke in children: data from the nationwide inpatient sample. Stroke 2007 38(6):1850-4.

Qureshi AI, Suri FK, Ahmed S, Nasar A, Divani AA, Kirmani JF. Regular egg consumption does not increase the risk of stroke and cardiovascular diseases. Med Sci Monit 2007 13(1):CR1-8.

Qureshi AI, Suri MF, Nasar A, Kirmani JF, Ezzeddine MA, Divani AA, Giles WH. Changes in Cost and Outcome Among US Patients With Stroke Hospitalized in 1990 to 1991 and Those Hospitalized in 2000 to 2001. Stroke 2007.

Qureshi AI. Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH): Rationale and Design. Neurocrit Care 2007 6(1):56-66.

Qureshi AI. Carotid angioplasty and stent placement after EVA-3S trial. Stroke 2007 38(6):1993-6.

Rodriguez GJ, Kirmani JF, Ezzeddine MA, Qureshi AI. Primary percutaneous transluminal angioplasty for early moyamoya disease. J Neuroimaging 2007 17(1):48-53.

Tejada JG, Taylor RA, Ugurel MS, Hayakawa M, Lee SK, Chaloupka JC. Safety and feasibility of intra-arterial nicardipine for the treatment of subarachnoid hemorrhage-associated vasospasm: initial clinical experience with high-dose infusions. AJNR Am J Neuroradiol 2007 28(5):844-8.

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